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161 In summary, dual and triple agonists related to GLP-1 represent significant advances in the field of diabetes treatment, 167,168 demonstrating the future trend of enhancing therapeutic effects by targeting multiple biomarkers
It is worth noting that the active ingredient semaglutide is a synthetic peptide, and the formulation also contains excipients including disodium phosphate dihydrate, propylene glycol, and phenol, as listed in the current SmPC
Interestingly, introduction of carboxylic acid groups to RT slows down its reaction kinetics towards GSH comparing to RT-NH 2 and TQG-CN (Table 2), presumably due to the charge repulsion between the carboxylic acid groups and the anionic GSH
A similar response was obtained in WT islets treated with the GLP-1R antagonist exendin-3
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